Cúrcuma

Hierba vivaz y resistente que puede alcanzar una altura de 90 cm. Sus hojas son grandes, verdes, oblongas y afiladas. Sus flores, de color amarillo pálido, se agrupan en espigas. Su rizoma fresco tiene la piel de color beis y la carne de color naranja vivo.

Nombre latino

Curcuma longa L.

Origen

Sur de Asia – India.

Parte utilzada

Los rizomas.

Ingredientes activos

Curcuminas: polifenoles con acción antioxidante y antiinflamatoria.
Carotenos: antioxidantes hidrosolubles.
Aceite esencial: responsable del aroma.

Uso

La cúrcuma es uno de los principales ingredientes de muchos platos asiáticos, así como del polvo de curry. Tiene un sabor terroso, un poco amargo y picante, y un olor parecido al de la mostaza.
La cúrcuma es un conservante y colorante natural.
En la Europa medieval, la cúrcuma se convirtió en el “azafrán de las Indias”, ya que se utilizó mucho como alternativa a la especia del azafrán, mucho más cara, para dar color a la comida. En la actualidad, la cúrcuma se utiliza para dar color a quesos, yogures, mantequilla y margarina. La cúrcuma se utiliza también para dar un color amarillo a algunas mostazas y otros productos alimentarios.
La cúrcuma se utiliza habitualmente para colorear los tejidos de prendas como los saris y las túnicas de los monjes budistas. Algunos pueblos la aplican en el cuerpo durante determinados rituales.
La cúrcuma se utiliza en la medicina ayurvédica y china desde hace siglos.
En la India, se ha utilizado tradicionalmente para tratar las molestias de estómago y las afecciones hepáticas, así como para curar heridas y regular la menstruación.
De hecho, son sobre todo las curcuminas, compuestos polifenólicos, las responsables de la mayor parte de los efectos en la salud. Ensayos clínicos han demostrado que la curcumina se puede utilizar de forma segura, incluso en dosis altas de 12 g diarios en el ser humano, pero presenta una escasa biodisponibilidad. Esto se debe a una baja absorción oral, debido a su solubilidad en agua extremadamente baja y al metabolismo presistémico de esta molécula.
Ha habido muchos intentos de mejorar la biodisponibilidad de la curcumina. En estos casos se recurre en primer lugar al uso de adyuvantes como la piperina. En la actualidad se han podido obtener unos resultados mucho mejores gracias a la microinclusión de la molécula en la beta-ciclodextrina o los fitosomas.
Gracias a su acción antioxidante, la curcumina ofrece protección celular al organismo. _1-10Ayuda a controlar las respuestas inflamatorias. _11-63
Contribuye a la buena salud y al funcionamiento correcto del hígado _64-98 y del sistema digestivo. _99-132
La curcumina contribuye a la salud del sistema locomotor. Ayuda a proteger y mantener la flexibilidad de las articulaciones, los tendones y los músculos, así como a aliviar los dolores inflamatorios. _133-153

Referencias bibliográficas

Antioxidant food supplements and obesity-related inflammation.
Mangge H, Summers K, Almer G, Prassl R, Weghuber D, Schnedl W, Fuchs D.
Curr Med Chem. 2013;20(18):2330-7.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/23531214
Free radical scavenging activity of curcuminoids.
Sreejayan N, Rao MN.
Arzneimittelforschung. 1996 Feb;46(2):169-71.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/8720307
Discovery of Curcumin, a Component of the Golden Spice, and Its Miraculous Biological Activities
Gupta SC, Patchva S, Koh W, Aggarwal BB.
Clin Exp Pharmacol Physiol. 2012 Mar;39(3):283-99.
PMC: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3288651/
Antioxidant Curcuma extracts decrease the blood lipid peroxide levels of human subjects
Ana Ramirez-Boscá, Alfonso Soler, Miguel Angel Carrión Gutierrez, Juan Laborda Alvarez, Eliseo Quintanilla Almagro
Journal of the American Aging Association 09/1995; 18(4):167-169.
ResearchGate: http://www.researchgate.net/publication/225480131_Antioxidant_Curcuma_extracts_decrease_the_blood_lipid_peroxide_levels_of_human_subjects
Protective effect of dietary curcumin and capsaicin on induced oxidation of low-density lipoprotein, iron-induced hepatotoxicity and carrageenan-induced inflammation in experimental rats.
Manjunatha H, Srinivasan K.
FEBS J. 2006 Oct;273(19):4528-37.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/16956363
Nitric oxide scavenging by curcuminoids.
Sreejayan, Rao MN.
J Pharm Pharmacol. 1997 Jan;49(1):105-7.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/9120760
Protective effect of curcumin on experimentally induced inflammation, hepatotoxicity and cardiotoxicity in rats: evidence of its antioxidant property.
Naik SR, Thakare VN, Patil SR.
Exp Toxicol Pathol. 2011 Jul;63(5):419-31.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/20363603
The promise of slow down ageing may come from curcumin.
Sikora E, Bielak-Zmijewska A, Mosieniak G, Piwocka K.
Curr Pharm Des. 2010;16(7):884-92.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/20388102
Curcumin, inflammation, ageing and age-related diseases.
Sikora E, Scapagnini G, Barbagallo M.
Immun Ageing. 2010 Jan 17;7(1):1.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/20205886
Phase I clinical trials of curcumin, a chemopreventative agent in patients with high-risk or pre-malignant lesions.
Cheng AL, Hsu CH, Lin JK, et al.
Anticancer Res. 2001;21:2895-2900.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/11712783
Curcumin in inflammatory diseases.
Shehzad A, Rehman G, Lee YS.
Biofactors. 2013 Jan-Feb;39(1):69-77.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/23281076
Inhibition of 5-hydroxy-eicosatetraenoic acid (5-HETE) formation in intact human neutrophils by naturally-occurring diarylheptanoids: inhibitory activities of curcuminoids and yakuchinones.
Flynn DL, Rafferty MF, Boctor AM.
Prostaglandins Leukot Med. 1986 Jun;22(3):357-60.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/3460103
Curcumin, a major component of food spice turmeric (Curcuma longa) inhibits aggregation and alters eicosanoid metabolism in human blood platelets.
Srivastava KC, Bordia A, Verma SK.
Prostaglandins Leukot Essent Fatty Acids. 1995 Apr;52(4):223-7.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/7784468
Mechanism of antiinflammatory actions of curcumine and boswellic acids.
Ammon HP, Safayhi H, Mack T, Sabieraj J.
J Ethnopharmacol. 1993 Mar;38(2-3):113-9.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/8510458
Inhibition of neutrophil response by curcumin.
Srivastava R.
Agents Actions. 1989 Nov;28(3-4):298-303.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/2556903
Curcumin inhibition of inflammatory cytokine production by human peripheral blood monocytes and alveolar macrophages.
Abe Y, Hashimoto S, Horie T.
Pharmacol Res. 1999 Jan;39(1):41-7.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/10051376
Effect of curcumin and capsaicin on arachidonic acid metabolism and lysosomal enzyme secretion by rat peritoneal macrophages.
Joe B, Lokesh BR.
Lipids. 1997 Nov;32(11):1173-80.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/9397403
Curcumin, a Curcuma longa constituent, acts on MAPK p38 pathway modulating COX-2 and iNOS expression in chronic experimental colitis.
Camacho-Barquero L, Villegas I, Sánchez-Calvo JM, Talero E, Sánchez-Fidalgo S, Motilva V, Alarcón de la Lastra C.
Int Immunopharmacol. 2007 Mar;7(3):333-42.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/17276891
Enhancement of wound healing by curcumin in animals.
Sidhu GS, Singh AK, Thaloor D, Banaudha KK, Patnaik GK, Srimal RC, Maheshwari RK.
Wound Repair Regen. 1998 Mar-Apr;6(2):167-77.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/9776860
Effects of dietary fats and curcumin on IgE-mediated degranulation of intestinal mast cells in brown Norway rats.
Ju HR, Wu HY, Nishizono S, Sakono M, Ikeda I, Sugano M, Imaizumi K.
Biosci Biotechnol Biochem. 1996 Nov;60(11):1856-60.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/8987863
Efficacy of curcumin in the management of chronic anterior uveitis.
Lal B, Kapoor AK, Asthana OP, Agrawal PK, Prasad R, Kumar P, Srimal RC.
Phytother Res. 1999 Jun;13(4):318-22.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/10404539
Role of curcumin in idiopathic inflammatory orbital pseudotumours.
Lal B, Kapoor AK, Agrawal PK, Asthana OP, Srimal RC.
Phytother Res. 2000;14:443-447.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/10960899
Regulation of inflammation and redox signaling by dietary polyphenols.
Rahman I, Biswas SK, Kirkham PA.
Biochem Pharmacol. 2006 Nov 30;72(11):1439-52.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/16920072
Curcumin as "Curecumin": from kitchen to clinic.
Goel A, Kunnumakkara AB, Aggarwal BB.
Biochem Pharmacol. 2008 Feb 15;75(4):787-809.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/17900536
Multi-targeted therapy by curcumin: how spicy is it?
Goel A, Jhurani S, Aggarwal BB.
Mol Nutr Food Res. 2008 Sep;52(9):1010-30.
Curcumin in New Zealand: http://www.curcumin.co.nz/pdf/Curcumin_Multi-Targeted_Thereapy.pdf
Curcumin, demethoxycurcumin, bisdemethoxycurcumin, tetrahydrocurcumin and turmerones differentially regulate anti-inflammatory and anti-proliferative responses through a ROS-independent mechanism
Santosh K. Sandur, Manoj K. Pandey, Bokyung Sung, Kwang Seok Ahn, Akira Murakami1, Gautam Sethi, Pornngarm Limtrakul2, Vladimir Badmaev3 and Bharat B. Aggarwal
Carcinogenesis (2007) 28 (8): 1765-1773.
Oxford Journals: http://carcin.oxfordjournals.org/content/28/8/1765.full
Evaluation of anti-inflammatory property of curcumin (diferuloyl methane) in patients with postoperative inflammation.
Satoskar RR, Shah SJ, Shenoy SG.
Int J Clin Pharmacol Ther Toxicol. 1986 Dec;24(12):651-4.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/3546166
Activation of transcription factor NF-kappa B is suppressed by curcumin (diferuloylmethane).
Singh S, Aggarwal BB.
J Biol Chem. 1995 Oct 20;270(42):24995-5000.
The Journal of Biological Chemistry: http://www.jbc.org/content/270/42/24995.full.pdf+html
Inhibitory effects of curcumin on in vitro lipoxygenase and cyclooxygenase activities in mouse epidermis.
Huang MT, Lysz T, Ferraro T, Abidi TF, Laskin JD, Conney AH.
Cancer Res. 1991 Feb 1;51(3):813-9.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/1899046
Curcumin, an anti-tumour promoter and anti-inflammatory agent, inhibits induction of nitric oxide synthase in activated macrophages.
Brouet I, Ohshima H.
Biochem Biophys Res Commun. 1995 Jan 17;206(2):533-40.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/7530002
Inhibition of tumor necrosis factor by curcumin, a phytochemical.
Chan MM.
Biochem Pharmacol. 1995 May 26;49(11):1551-6.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/7786295
Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-kappa B activation.
Surh YJ, Chun KS, Cha HH, Han SS, Keum YS, Park KK, Lee SS.
Mutat Res. 2001 Sep 1;480-481:243-68.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/11506818
Targeting inflammation-induced obesity and metabolic diseases by curcumin and other nutraceuticals.
Aggarwal BB.
Annu Rev Nutr. 2010 Aug 21;30:173-99.
PMC: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3144156/
Cyclodextrin-complexed curcumin exhibits anti-inflammatory and antiproliferative activities superior to those of curcumin through higher cellular uptake.
Yadav VR, Prasad S, Kannappan R, Ravindran J, Chaturvedi MM, Vaahtera L, Parkkinen J, Aggarwal BB.
Biochem Pharmacol. 2010 Oct 1;80(7):1021-32.
PMC: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2923254/
Potential therapeutic effects of curcumin, the anti-inﬂammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases.
Aggarwal BB, Harikumar KB.
Int J Biochem Cell Biol. 2009 Jan;41(1):40-59.
Curcumin Research: http://www.curcuminresearch.org/PDF/Aggarwal%20BB-2.pdf
Curcumin attenuates allergic airway inflammation by regulation of CD4(+)CD25(+) regulatory T cells (Tregs)/Th17 balance in ovalbumin-sensitized mice.
Ma C, Ma Z, Fu Q, Ma S.
Fitoterapia. 2013 Jun;87:57-64.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/23500387
Modulation of adipose tissue inflammation by bioactive food compounds.
Siriwardhana N, Kalupahana NS, Cekanova M, LeMieux M, Greer B, Moustaid-Moussa N.
J Nutr Biochem. 2013 Apr;24(4):613-23.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/23498665
Curcumin modulates the inflammatory response and inhibits subsequent fibrosis in a mouse model of viral-induced acute respiratory distress syndrome.
Avasarala S, Zhang F, Liu G, Wang R, London SD, London L.
PLoS One. 2013;8(2):e57285.
PMC: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3577717/
Curcumin: An Orally Bioavailable Blocker of TNF and Other Pro-inflammatory Biomarkers.
Aggarwal BB, Gupta SC, Sung B.
Br J Pharmacol. 2013 Feb 20.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/23425071
Curcumin alleviates oxidative stress, inflammation, and renal fibrosis in remnant kidney through the Nrf2-keap1 pathway.
Soetikno V, Sari FR, Lakshmanan AP, Arumugam S, Harima M, Suzuki K, Kawachi H, Watanabe K.
Mol Nutr Food Res. 2012 Nov 23.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/23174956
A randomized controlled trial on the anti-inflammatory effects of curcumin in patients with chronic sulphur mustard-induced cutaneous complications.
Panahi Y, Sahebkar A, Parvin S, Saadat A.
Ann Clin Biochem. 2012 Nov;49(Pt 6):580-8.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/23038702
Anti-inflammatory potential of curcumin and quercetin in rats: Role of oxidative stress, heme oxygenase-1 and TNF-α
Heeba GH, Mahmoud ME, El Hanafy AA.
Toxicol Ind Health. 2012 Sep 28.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/23024111
Curcumin suppresses ovalbumin-induced allergic conjunctivitis.
Chung SH, Choi SH, Choi JA, Chuck RS, Joo CK.
Mol Vis. 2012;18:1966-72.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/22876123
Curcumin inhibits inflammatory response and bone loss during experimental periodontitis in rats.
Zhou T, Chen D, Li Q, Sun X, Song Y, Wang C.
Acta Odontol Scand. 2013 Mar;71(2):349-56.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/22554269
Neuroprotective effect of curcuminoids against inflammation-mediated dopaminergic neurodegeneration in the MPTP model of Parkinson's disease.
Ojha RP, Rastogi M, Devi BP, Agrawal A, Dubey GP.
J Neuroimmune Pharmacol. 2012 Sep;7(3):609-18.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/22527634
Curcumin attenuates TNF-α-induced expression of intercellular adhesion molecule-1, vascular cell adhesion molecule-1 and proinflammatory cytokines in human endometriotic stromal cells.
Kim KH, Lee EN, Park JK, Lee JR, Kim JH, Choi HJ, Kim BS, Lee HW, Lee KS, Yoon S.
Phytother Res. 2012 Jul;26(7):1037-47.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/22183741
Curcumin ameliorates cardiac inflammation in rats with autoimmune myocarditis.
Mito S, Watanabe K, Harima M, Thandavarayan RA, Veeraveedu PT, Sukumaran V, Suzuki K, Kodama M, Aizawa Y.
Biol Pharm Bull. 2011;34(7):974-9.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/21720000
Curcumin attenuates lipopolysaccharide-induced renal inflammation.
Zhong F, Chen H, Han L, Jin Y, Wang W.
Biol Pharm Bull. 2011;34(2):226-32.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/21415532
Modulation of steroid activity in chronic inflammation: a novel anti-inflammatory role for curcumin.
Biswas S, Rahman I.
Mol Nutr Food Res. 2008 Sep;52(9):987-94.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/18327875
Mechanism of the Anti-inflammatory Effect of Curcumin: PPAR-gamma Activation.
Jacob A, Wu R, Zhou M, Wang P.
PPAR Res. 2007;2007:89369.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/18274631
Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: a review of preclinical and clinical research.
Jurenka JS.
Altern Med Rev. 2009 Jun;14(2):141-53.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/19594223
Anti-inflammatory effect of curcumin involves downregulation of MMP-9 in blood mononuclear cells.
Saja K, Babu MS, Karunagaran D, Sudhakaran PR.
Int Immunopharmacol. 2007 Dec 15;7(13):1659-67.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/17996675
Curcumin attenuates inflammatory responses of TNF-alpha-stimulated human endothelial cells.
Kim YS, Ahn Y, Hong MH, Joo SY, Kim KH, Sohn IS, Park HW, Hong YJ, Kim JH, Kim W, Jeong MH, Cho JG, Park JC, Kang JC.
J Cardiovasc Pharmacol. 2007 Jul;50(1):41-9.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/17666914
Beneficial role of curcumin in skin diseases.
Thangapazham RL, Sharma A, Maheshwari RK.
Adv Exp Med Biol. 2007;595:343-57.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/17569219
Regulation of COX and LOX by curcumin.
Rao CV.
Adv Exp Med Biol. 2007;595:213-26.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/17569213
Antioxidant and anti-inflammatory properties of curcumin.
Menon VP, Sudheer AR.
Adv Exp Med Biol. 2007;595:105-25.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/17569207
Effects of curcumin on retinal oxidative stress and inflammation in diabetes.
Kowluru RA, Kanwar M.
Nutr Metab (Lond). 2007 Apr 16;4:8.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/17437639
Curcumin inhibits the expression of COX-2 in UVB-irradiated human keratinocytes (HaCaT) by inhibiting activation of AP-1: p38 MAP kinase and JNK as potential upstream targets.
Cho JW, Park K, Kweon GR, Jang BC, Baek WK, Suh MH, Kim CW, Lee KS, Suh SI.
Exp Mol Med. 2005 Jun 30;37(3):186-92.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/16000872
Inhibition of cyclo-oxygenase 2 expression in colon cells by the chemopreventive agent curcumin involves inhibition of NF-kappaB activation via the NIK/IKK signalling complex.
Plummer SM, Holloway KA, Manson MM, Munks RJ, Kaptein A, Farrow S, Howells L.
Oncogene. 1999 Oct 28;18(44):6013-20.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/10557090
Curcumin blocks cytokine-mediated NF-kappa B activation and proinflammatory gene expression by inhibiting inhibitory factor I-kappa B kinase activity.
Jobin C, Bradham CA, Russo MP, Juma B, Narula AS, Brenner DA, Sartor RB.
J Immunol. 1999 Sep 15;163(6):3474-83.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/10477620
Enhancement of wound healing by curcumin in animals.
Sidhu GS, Singh AK, Thaloor D, Banaudha KK, Patnaik GK, Srimal RC, Maheshwari RK.
Wound Repair Regen. 1998 Mar-Apr;6(2):167-77.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/9776860
In vivo inhibition of nitric oxide synthase gene expression by curcumin, a cancer preventive natural product with anti-inflammatory properties.
Chan MM, Huang HI, Fenton MR, Fong D.
Biochem Pharmacol. 1998 Jun 15;55(12):1955-62.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/9714315
Safety and anti-inflammatory activity of curcumin: a component of tumeric (Curcuma longa).
Chainani-Wu N.
J Altern Complement Med. 2003 Feb;9(1):161-8.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/12676044
Fat digestion and absorption in spice-pretreated rats.
Prakash UN, Srinivasan K.
J Sci Food Agric. 2011 Sep 14.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/21918995
The effect of curcumin and placebo on human gall-bladder function: an ultrasound study.
Rasyid A, Lelo A.
Aliment Pharmacol Ther. 1999 Feb;13(2):245-9.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/10102956
The role of antioxidants and other agents in alleviating hyperglycemia mediated oxidative stress and injury in liver.
Dey A, Lakshmanan J.
Food Funct. 2013 Jun 12.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/23760593
Curcumin prevents alcohol-induced liver disease in rats by inhibiting the expression of NF-kappa B-dependent genes.
Nanji AA, Jokelainen K, Tipoe GL, Rahemtulla A, Thomas P, Dannenberg AJ.
Am J Physiol Gastrointest Liver Physiol. 2003 Feb;284(2):G321-7.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/12388178
Curcumin inhibits NF-kappaB activation and reduces the severity of experimental steatohepatitis in mice.
Leclercq IA, Farrell GC, Sempoux C, dela Peña A, Horsmans Y.
J Hepatol. 2004 Dec;41(6):926-34.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/15582125
Curcumin attenuated paracetamol overdose induced hepatitis.
Somanawat K, Thong-Ngam D, Klaikeaw N.
World J Gastroenterol. 2013 Mar 28;19(12):1962-7.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/23569342
Positive effect of curcumin on inflammation and mitochondrial dysfunction in obese mice with liver steatosis.
Kuo JJ, Chang HH, Tsai TH, Lee TY.
Int J Mol Med. 2012 Sep;30(3):673-9.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/22751848
Curcumin protects against thioacetamide-induced hepatic fibrosis by attenuating the inflammatory response and inducing apoptosis of damaged hepatocytes.
Wang ME, Chen YC, Chen IS, Hsieh SC, Chen SS, Chiu CH.
J Nutr Biochem. 2012 Oct;23(10):1352-66.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/22221674
Protective effects of curcumin against hepatic fibrosis induced by carbon tetrachloride: modulation of high-mobility group box 1, Toll-like receptor 4 and 2 expression.
Tu CT, Yao QY, Xu BL, Wang JY, Zhou CH, Zhang SC.
Food Chem Toxicol. 2012 Sep;50(9):3343-51.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/22683883
The protective effect of curcumin on ischemia-reperfusion-induced liver injury.
Lin CM, Lee JF, Chiang LL, Chen CF, Wang D, Su CL.
Transplant Proc. 2012 May;44(4):974-7.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/22564600
Inhibitory effect of curcumin on liver injury in a murine model of endotoxemic shock.
Yun SS, Kim SP, Kang MY, Nam SH.
Biotechnol Lett. 2010 Feb;32(2):209-14.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/19856147
Curcumin adds spice to the debate: lipid metabolism in liver disease.
Graham A.
Br J Pharmacol. 2009 Aug;157(8):1352-3.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/19681867
Curcumin decreased oxidative stress, inhibited NF-kappaB activation, and improved liver pathology in ethanol-induced liver injury in rats.
Samuhasaneeto S, Thong-Ngam D, Kulaputana O, Suyasunanont D, Klaikeaw N.
J Biomed Biotechnol. 2009;2009:981963.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/19606259
Curcumin protects the rat liver from CCl4-caused injury and fibrogenesis by attenuating oxidative stress and suppressing inflammation.
Fu Y, Zheng S, Lin J, Ryerse J, Chen A.
Mol Pharmacol. 2008 Feb;73(2):399-409.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/18006644
Curcumin protects against acute liver damage in the rat by inhibiting NF-kappaB, proinflammatory cytokines production and oxidative stress.
Reyes-Gordillo K, Segovia J, Shibayama M, Vergara P, Moreno MG, Muriel P.
Biochim Biophys Acta. 2007 Jun;1770(6):989-96.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/17383825
Therapeutic potential of curcumin in non-alcoholic steatohepatitis.
Shapiro H, Bruck R.
Nutr Res Rev. 2005 Dec;18(2):212-21.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/19079906
Inhibition by curcumin of diethylnitrosamine-induced hepatic hyperplasia, inflammation, cellular gene products and cell-cycle-related proteins in rats.
Chuang SE, Cheng AL, Lin JK, Kuo ML.
Food Chem Toxicol. 2000 Nov;38(11):991-5.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/11038236
Pharmacological actions of curcumin in liver diseases or damage.
Rivera-Espinoza Y, Muriel P.
Liver Int. 2009 Nov;29(10):1457-66.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/19811613
Alcohol metabolites and lipopolysaccharide: roles in the development and/or progression of alcoholic liver disease.
Schaffert CS, Duryee MJ, Hunter CD, Hamilton BC 3rd, DeVeney AL, Huerter MM, Klassen LW, Thiele GM.
World J Gastroenterol. 2009 Mar 14;15(10):1209-18.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/19291821
Nephroprotective and hepatoprotective effects of curcuminoids.
Osawa T.
Adv Exp Med Biol. 2007;595:407-23.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/17569222
Effects of curcumin intake on kidney and liver pathological changes in T2DM rats.
Sun C, Zhang Y, Kong T, Li Y, Feng R, Wang G.
Wei Sheng Yan Jiu. 2013 Jan;42(1):6-9.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/23596699
Curcumin prevents liver fat accumulation and serum fetuin-A increase in rats fed a high-fat diet.
Oner-İyidoğan Y, Koçak H, Seyidhanoğlu M, Gürdöl F, Gülçubuk A, Yildirim F, Cevik A, Uysal M.
J Physiol Biochem. 2013 Feb 22.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/23430567
Protective effects of curcumin against oxidative stress parameters and DNA damage in the livers and kidneys of rats with biliary obstruction.
Tokaç M, Taner G, Aydın S, Ozkardeş AB, Dündar HZ, Taşlıpınar MY, Arıkök AT, Kılıç M, Başaran AA, Basaran N.
Food Chem Toxicol. 2013 Jan 29. pii: S0278-6915(13)00053-7.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/23376509
Antioxidative, antiapoptotic, and proliferative effect of curcumin on liver regeneration after partial hepatectomy in rats.
Toydemir T, Kanter M, Erboga M, Oguz S, Erenoglu C.
Toxicol Ind Health. 2013 Jan 8.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/23299190
Hepatoprotective effect of curcumin in lipopolysaccharide/-galactosamine model of liver injury in rats: relationship to HO-1/CO antioxidant system.
Fitoterapia. 2011 Jul;82(5):786-91.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/21545828
Efficacy of curcumin to reduce hepatic damage induced by alcohol and thermally treated oil in rats.
El-Deen NA, Eid M.
Vet Ital. 2010 Jan-Mar;46(1):83-92.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/20391370
Curcumin inhibits hepatic protein-tyrosine phosphatase 1B and prevents hypertriglyceridemia and hepatic steatosis in fructose-fed rats.
Li JM, Li YC, Kong LD, Hu QH.
Hepatology. 2010 May;51(5):1555-66.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/20222050
Curcumin alleviates ethanol-induced hepatocytes oxidative damage involving heme oxygenase-1 induction.
Bao W, Li K, Rong S, Yao P, Hao L, Ying C, Zhang X, Nussler A, Liu L.
J Ethnopharmacol. 2010 Mar 24;128(2):549-53.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/20080166
Curcumin limits the fibrogenic evolution of experimental steatohepatitis.
Vizzutti F, Provenzano A, Galastri S, Milani S, Delogu W, Novo E, Caligiuri A, Zamara E, Arena U, Laffi G, Parola M, Pinzani M, Marra F.
Lab Invest. 2010 Jan;90(1):104-15.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/19901911
Curcumin prevents liver fibrosis by inducing apoptosis and suppressing activation of hepatic stellate cells.
Shu JC, He YJ, Lv X, Ye GR, Wang LX.
J Nat Med. 2009 Oct;63(4):415-20.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/19554395
Curcumin ameliorates rabbits's steatohepatitis via respiratory chain, oxidative stress, and TNF-alpha.
Ramirez-Tortosa MC, Ramirez-Tortosa CL, Mesa MD, Granados S, Gil A, Quiles JL.
Free Radic Biol Med. 2009 Oct 1;47(7):924-31.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/19539747
Study on antifibrotic effects of curcumin in rat hepatic stellate cells.
Lin YL, Lin CY, Chi CW, Huang YT.
Phytother Res. 2009 Jul;23(7):927-32.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/19152370
Effect of curcumin on the increase in hepatic or brain phosphatidylcholine hydroperoxide levels in mice after consumption of excessive alcohol.
Pyun CW, Han KH, Hong GE, Lee CH.
Biomed Res Int. 2013;2013:242671.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/23607090
Detoxification and antioxidant effects of curcumin in rats experimentally exposed to mercury.
Agarwal R, Goel SK, Behari JR.
J Appl Toxicol. 2010 Jul;30(5):457-68.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/20229497
Effect of different curcuminoid supplement dosages on total in vivo antioxidant capacity and cholesterol levels of healthy human subjects.
Pungcharoenkul K, Thongnopnua P.
Phytother Res. 2011 Nov;25(11):1721-6.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/21796707
Randomized double blind study of Curcuma domestica Val. for dyspepsia.
Thamlikitkul V, Bunyapraphatsara N, Dechatiwongse T, Theerapong S, Chantrakul C, Thanaveerasuwan T, Nimitnon S, Boonroj P, Punkrut W, Gingsungneon V, et al.
J Med Assoc Thai. 1989 Nov;72(11):613-20.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/2699615
Effect of oral curcumin administration on serum peroxides and cholesterol levels in human volunteers.
Soni KB, Kuttan R.
Indian J Physiol Pharmacol. 1992 Oct;36(4):273-5.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/1291482
Effect of curcumin on acidic pH-induced expression of IL-6 and IL-8 in human esophageal epithelial cells (HET-1A): role of PKC, MAPKs, and NF-kappaB.
Rafiee P, Nelson VM, Manley S, Wellner M, Floer M, Binion DG, Shaker R.
Am J Physiol Gastrointest Liver Physiol. 2009 Feb;296(2):G388-98.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/19074641
Chemoprotective effects of curcumin in esophageal epithelial cells exposed to bile acids.
Bower MR, Aiyer HS, Li Y, Martin RC.
World J Gastroenterol. 2010 Sep 7;16(33):4152-8.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/20806431
Comparative antiulcer effect of bisdemethoxycurcumin and curcumin in a gastric ulcer model system.
Mahattanadul S, Nakamura T, Panichayupakaranant P, Phdoongsombut N, Tungsinmunkong K, Bouking P.
Phytomedicine. 2009 Apr;16(4):342-51.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/19188055
Curcumin prevents indomethacin-induced gastropathy in rats.
Thong-Ngam D, Choochuai S, Patumraj S, Chayanupatkul M, Klaikeaw N.
World J Gastroenterol. 2012 Apr 7;18(13):1479-84.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/22509079
Curcuma longa extract protects against gastric ulcers by blocking H2 histamine receptors.
Kim DC, Kim SH, Choi BH, Baek NI, Kim D, Kim MJ, Kim KT.
Biol Pharm Bull. 2005 Dec;28(12):2220-4.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/16327153
Curcumin heals indomethacin-induced gastric ulceration by stimulation of angiogenesis and restitution of collagen fibers via VEGF and MMP-2 mediated signaling.
Sharma AV, Ganguly K, Paul S, Maulik N, Swarnakar S.
Antioxid Redox Signal. 2012 Feb 15;16(4):351-62.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/21942294
Curcumin suppresses gastric NF-kappaB activation and macromolecular leakage in Helicobacter pylori-infected rats.
Sintara K, Thong-Ngam D, Patumraj S, Klaikeaw N, Chatsuwan T.
World J Gastroenterol. 2010 Aug 28;16(32):4039-46.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/20731017
Investigation of the anti-inflammatory effect of Curcuma longa in Helicobacter pylori-infected patients.
Koosirirat C, Linpisarn S, Changsom D, Chawansuntati K, Wipasa J.
Int Immunopharmacol. 2010 Jul;10(7):815-8.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/20438867
Anti-ulcer activity of curcumin on experimental gastric ulcer in rats and its effect on oxidative stress/antioxidant, IL-6 and enzyme activities.
Tuorkey M, Karolin K.
Biomed Environ Sci. 2009 Dec;22(6):488-95.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/20337222
Antimicrobial activity of curcumin against Helicobacter pylori isolates from India and during infections in mice.
De R, Kundu P, Swarnakar S, Ramamurthy T, Chowdhury A, Nair GB, Mukhopadhyay AK.
Antimicrob Agents Chemother. 2009 Apr;53(4):1592-7.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/19204190
Preventive action of curcumin in experimental acute pancreatitis in mouse.
Yu WG, Xu G, Ren GJ, Xu X, Yuan HQ, Qi XL, Tian KL.
Indian J Med Res. 2011 Nov;134(5):717-24.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/22199113
Modulation of intestinal mucosal inflammatory factors by curcumin in rats with colitis.
Jian YT, Wang JD, Mai GF, Zhang YL, Lai ZS.
Di Yi Jun Yi Da Xue Xue Bao. 2004 Dec;24(12):1353-8.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/15604057
Pancreatic stellate cells: new target in the treatment of chronic pancreatitis.
Talukdar R, Tandon RK.
J Gastroenterol Hepatol. 2008 Jan;23(1):34-41.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/17995943
Anti-inflammatory effects of resveratrol, curcumin and simvastatin in acute small intestinal inflammation.
Bereswill S, Muñoz M, Fischer A, Plickert R, Haag LM, Otto B, Kühl AA, Loddenkemper C, Göbel UB, Heimesaat MM.
PLoS One. 2010 Dec 3;5(12):e15099.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/21151942
IL-1beta causes an increase in intestinal epithelial tight junction permeability.
Al-Sadi RM, Ma TY.
J Immunol. 2007 Apr 1;178(7):4641-9.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/17372023
Anti-inflammatory effects of dietary phenolic compounds in an in vitro model of inflamed human intestinal epithelium.
Sergent T, Piront N, Meurice J, Toussaint O, Schneider YJ.
Chem Biol Interact. 2010 Dec 5;188(3):659-67.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/20816778
Modulation of neutrophil motility by curcumin: implications for inflammatory bowel disease.
Larmonier CB, Midura-Kiela MT, Ramalingam R, Laubitz D, Janikashvili N, Larmonier N, Ghishan FK, Kiela PR.
Inflamm Bowel Dis. 2011 Feb;17(2):503-15.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/20629184
Effects of oral curcumin on indomethacin-induced small intestinal damage in the rat.
Menozzi A, Pozzoli C, Poli E, Martelli M, Martelli L, Zullian C, Bertini S.
Drug Discov Ther. 2009 Apr;3(2):71-6.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/22495480
The effects of dietary curcumin and rutin on colonic inflammation and gene expression in multidrug resistance gene-deficient (mdr1a-/-) mice, a model of inflammatory bowel diseases.
Nones K, Dommels YE, Martell S, Butts C, McNabb WC, Park ZA, Zhu S, Hedderley D, Barnett MP, Roy NC.
Br J Nutr. 2009 Jan;101(2):169-81.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/18761777
Effects of curcumin and Ginkgo biloba on matrix metalloproteinases gene expression and other biomarkers of inflammatory bowel disease.
Motawi TK, Rizk SM, Shehata AH.
J Physiol Biochem. 2012 Dec;68(4):529-39.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/22535283
Tolerability of curcumin in pediatric inflammatory bowel disease: a forced-dose titration study.
Suskind DL, Wahbeh G, Burpee T, Cohen M, Christie D, Weber W.
J Pediatr Gastroenterol Nutr. 2013 Mar;56(3):277-9.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/23059643
Curcumin and inflammatory bowel disease: biological mechanisms and clinical implication.
Ali T, Shakir F, Morton J.
Digestion. 2012;85(4):249-55.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/22950087
Effects of curcumin on the intestinal motility of albino rats.
Kumar A, Purwar B, Shrivastava A, Pandey S.
Indian J Physiol Pharmacol. 2010 Jul-Sep;54(3):284-8.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/21409867
Curcumin for inflammatory bowel disease: a review of human studies.
Taylor RA, Leonard MC
Altern Med Rev. 2011 Jun;16(2):152-6.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/21649456
Curcumin inhibits cholesterol uptake in Caco-2 cells by down-regulation of NPC1L1 expression.
Feng D, Ohlsson L, Duan RD.
Lipids Health Dis. 2010 Apr 19;9:40.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/20403165
Curcumin has bright prospects for the treatment of inflammatory bowel disease.
Hanai H, Sugimoto K.
Curr Pharm Des. 2009;15(18):2087-94.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/19519446
Clinical utility of curcumin extract.
Asher GN, Spelman K.
Altern Ther Health Med. 2013 Mar-Apr;19(2):20-2.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/23594449
Curcumin attenuates inflammation through inhibition of TLR-4 receptor in experimental colitis.
Lubbad A, Oriowo MA, Khan I.
Mol Cell Biochem. 2009 Feb;322(1-2):127-35.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/19002562
Curcumin reverses attenuated carbachol-induced contraction of the colon in a rat model of colitis.
Lubbad AS, Oriowo MA, Khan I.
Scand J Gastroenterol. 2009;44(2):187-94.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/18830899
Curcumin, an active component of turmeric in the prevention and treatment of ulcerative colitis: preclinical and clinical observations.
Baliga MS, Joseph N, Venkataranganna MV, Saxena A, Ponemone V, Fayad R.
Food Funct. 2012 Nov;3(11):1109-17.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/22833299
Effect of cyclodextrin complexation of curcumin on its solubility and antiangiogenic and anti-inflammatory activity in rat colitis model.
Yadav VR, Suresh S, Devi K, Yadav S.
AAPS PharmSciTech. 2009;10(3):752-62.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/19495987
Effect of dietary turmeric on breath hydrogen.
Shimouchi A, Nose K, Takaoka M, Hayashi H, Kondo T.
Dig Dis Sci. 2009 Aug;54(8):1725-9.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/19034660
Scientific Evidence and Rationale for the Development of Curcumin and Resveratrol as Nutraceutricals for Joint Health.
Int. J. Mol. Sci. 2012, 13, 4202-4232;
Ali Mobasheri, Yves Henrotin, Hans-Konrad Biesalski and Mehdi Shakibaei
PMC: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3344210/pdf/ijms-13-04202.pdf
Curcumin improves bone microarchitecture and enhances mineral density in APP/PS1 transgenic mice.
Yang MW, Wang TH, Yan PP, Chu LW, Yu J, Gao ZD, Li YZ, Guo BL.
Phytomedicine. 2011 Jan 15;18(2-3):205-13.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/20637579
Biological actions of curcumin on articular chondrocytes.
Henrotin Y, Clutterbuck AL, Allaway D, Lodwig EM, Harris P, Mathy-Hartert M, Shakibaei M, Mobasheri A.
Osteoarthritis Cartilage. 2010 Feb;18(2):141-9.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/19836480
Interleukin-1beta-induced extracellular matrix degradation and glycosaminoglycan release is inhibited by curcumin in an explant model of cartilage inflammation.
Clutterbuck AL, Mobasheri A, Shakibaei M, Allaway D, Harris P.
Ann N Y Acad Sci. 2009 Aug;1171:428-35.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/19723086
Curcumin inhibits pro-inflammatory mediators and metalloproteinase-3 production by chondrocytes.
Mathy-Hartert M, Jacquemond-Collet I, Priem F, Sanchez C, Lambert C, Henrotin Y.
Inflamm Res. 2009 Dec;58(12):899-908.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/19579007
Natural products as a gold mine for arthritis treatment.
Khanna D, Sethi G, Ahn KS, Pandey MK, Kunnumakkara AB, Sung B, Aggarwal A, Aggarwal BB.
Curr Opin Pharmacol. 2007 Jun;7(3):344-51.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/17475558
Curcumin effects on inflammation and performance recovery following eccentric exercise-induced muscle damage.
Davis JM, Murphy EA, Carmichael MD, Zielinski MR, Groschwitz CM, Brown AS, Gangemi JD, Ghaffar A, Mayer EP.
Am J Physiol Regul Integr Comp Physiol. 2007 Jun;292(6):R2168-73.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/17332159
Anti-inflammatory and anti-oxidant properties of Curcuma longa (turmeric) versus Zingiber officinale (ginger) rhizomes in rat adjuvant-induced arthritis.
Ramadan G, Al-Kahtani MA, El-Sayed WM.
Inflammation. 2011 Aug;34(4):291-301.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/21120596
The antioxidants curcumin and quercetin inhibit inflammatory processes associated with arthritis.
Jackson JK, Higo T, Hunter WL, Burt HM.
Inflamm Res. 2006 Apr;55(4):168-75.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/16807698
Turmeric extracts containing curcuminoids prevent experimental rheumatoid arthritis.
Funk JL, Oyarzo JN, Frye JB, Chen G, Lantz RC, Jolad SD, Sólyom AM, Timmermann BN.
J Nat Prod. 2006 Mar;69(3):351-5.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/16562833
Induction of matrix metalloproteinase-13 gene expression by TNF-alpha is mediated by MAP kinases, AP-1, and NF-kappaB transcription factors in articular chondrocytes.
Liacini A, Sylvester J, Li WQ, Huang W, Dehnade F, Ahmad M, Zafarullah M.
Exp Cell Res. 2003 Aug 1;288(1):208-17.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/12878172
Regulation of pro-inflammatory cytokine expression by curcumin in hyaline membrane disease (HMD).
Literat A, Su F, Norwicki M, Durand M, Ramanathan R, Jones CA, Minoo P, Kwong KY.
Life Sci. 2001 Dec 7;70(3):253-67.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/12005259
Efficacy and safety of Meriva®, a curcumin-phosphatidylcholine complex, during extended administration in osteoarthritis patients.
Belcaro G, Cesarone MR, Dugall M, Pellegrini L, Ledda A, Grossi MG, Togni S, Appendino G.
Altern Med Rev. 2010 Dec;15(4):337-44.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/21194249
Curcumin: a new paradigm and therapeutic opportunity for the treatment of osteoarthritis: curcumin for osteoarthritis management.
Henrotin Y, Priem F, Mobasheri A.
Springerplus. 2013 Dec;2(1):56.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/23487030
A randomized, pilot study to assess the efficacy and safety of curcumin in patients with active rheumatoid arthritis.
Chandran B, Goel A.
Phytother Res. 2012 Nov;26(11):1719-25.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/22407780
Short- and long-term exposure of articular cartilage to curcumin or quercetin inhibits aggrecan loss.
Lay E, Samiric T, Handley CJ, Ilic MZ.
J Nutr Biochem. 2012 Feb;23(2):106-12.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/21419610
Curcumin attenuates inflammatory response in IL-1beta-induced human synovial fibroblasts and collagen-induced arthritis in mouse model.
Moon DO, Kim MO, Choi YH, Park YM, Kim GY.
Int Immunopharmacol. 2010 May;10(5):605-10.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/20188213
Differential expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in anterior cruciate ligament and medial collateral ligament fibroblasts after a mechanical injury: involvement of the p65 subunit of NF-kappaB.
Tang Z, Yang L, Xue R, Zhang J, Wang Y, Chen PC, Sung KL.
Wound Repair Regen. 2009 Sep-Oct;17(5):709-16.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/19769723
Oral administration of curcumin suppresses production of matrix metalloproteinase (MMP)-1 and MMP-3 to ameliorate collagen-induced arthritis: inhibition of the PKCdelta/JNK/c-Jun pathway.
Mun SH, Kim HS, Kim JW, Ko NY, Kim do K, Lee BY, Kim B, Won HS, Shin HS, Han JW, Lee HY, Kim YM, Choi WS.
J Pharmacol Sci. 2009 Sep;111(1):13-21.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/19763044
Decreased activity of neutrophils in the presence of diferuloylmethane (curcumin) involves protein kinase C inhibition.
Jancinová V, Perecko T, Nosál R, Kostálová D, Bauerová K, Drábiková K
Eur J Pharmacol. 2009 Jun 10;612(1-3):161-6.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/19371737
Inhibition effect of curcumin on TNF-α and MMP-13 expression induced by advanced glycation end products in chondrocytes.
Yang Q, Wu S, Mao X, Wang W, Tai H.
Pharmacology. 2013;91(1-2):77-85.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/23183190

Productos vinculados

30 comprimidos

Flexicur Articulaciones
Acción rápida

La cúrcuma ayuda a mantener la flexibilidad de las articulacionesDónde encontrarlo Puedes comprar los produc ...

Ver el producto

Las declaraciones de propiedades saludables relativas a las plantas que contienen los productos que figuran en nuestro sitio web son conformes a la lista de declaraciones de propiedades saludables en espera de evaluación definitiva por parte de las autoridades comunitarias (véase el sitio web de la Comisión Europea: http://ec.europa.eu/nuhclaims/). Sin embargo, pueden sufrir modificaciones tras su evaluación por las autoridades nacionales competentes.

Las declaraciones de propiedades saludables relativas a otros nutrientes o sustancias que contienen los productos que figuran en nuestro sitio web son conformes al Reglamento n.º 432/2012 de la Comisión, de 16 de mayo de 2012, por el que se establece una lista de declaraciones autorizadas de propiedades saludables de los alimentos distintas de las relativas a la reducción del riesgo de enfermedad y al desarrollo y la salud de los niños (véase el sitio web de la Comisión Europea: http://ec.europa.eu/nuhclaims/).