Royal Jelly

Origin

Proteins (royalsin): have an antibacterial effect. Essential amino acids: are rich in essential amino acids for the proper function of the organism. Complex of vitamins (especially B vitamins) and minerals: important for the cell metabolism. Organic acids: have a bacteriostatic and antifungal action Fatty acid (10-hydroxy-2-decenoic acid): considered a substance with antibacterial properties and used as a marker to verify the quality of pure and natural royal jelly. Neopterin: plays an essential role in the immune system. Sugars (comparable to honey): contribute to the nutritional content. Acetylcholine: essential neurotransmitter for the central nervous system.

Used part

Royal jelly is used as a component in a certain number of skincare products and natural beauty products. In traditional medicine, royal jelly is used to stimulate recovery, to protect the liver and as an immunomodulator. Since it is considered to stimulate and tone, it is often applied to obtain a sensation of well-being.

Bibliographical references

Neopterin: a review.
Hamerlinck FF.
Exp Dermatol. 1999 Jun;8(3):167-76.
Wiley Online Library:http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0625.1999.tb00367.x/pdf
Evaluation of (E)-10-hydroxydec-2-enoic acid as afreshness parameter for royal jelly
Jean-François Antinellia, Sarah Zegganea, Renée Davicoa,Catherine Rognonea, Jean-Paul Faucona, Louisette Lizzanib
Food Chemistry Volume 80, Issue 1, January 2003, Pages 85–89
Science Direct:http://www.sciencedirect.com/science/article/pii/S0308814602002431
Antifatigue effect of fresh royal jelly in mice.
Kamakura M, Mitani N, Fukuda T, Fukushima M.
J Nutr Sci Vitaminol (Tokyo). 2001 Dec;47(6):394-401.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/11922114
10-Hydroxy-delta 2-decenoic acid, an antibiotic found inroyal jelly.
BLUM MS, NOVAK AF, TABER S 3rd.
Science. 1959 Aug 21;130(3373):452-3.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/13675771
Effects of long-term administration of royal jelly onpituitary weight and gene expression in middle-aged female rats.
Narita Y, Ohta S, Suzuki KM, Nemoto T, Abe K, Mishima S.
Biosci Biotechnol Biochem. 2009 Feb;73(2):431-3.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/19202272
Royal jelly peptides inhibit lipid peroxidation in vitroand in vivo.
Guo H, Ekusa A, Iwai K, Yonekura M, Takahata Y, Morimatsu F.
J Nutr Sci Vitaminol (Tokyo). 2008 Jun;54(3):191-5.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/18635904
Royal Jelly prolongs the life span of C3H/HeJ mice:correlation with reduced DNA damage.
Inoue S, Koya-Miyata S, Ushio S, Iwaki K, Ikeda M, KurimotoM.
Exp Gerontol. 2003 Sep;38(9):965-9.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/12954483
Identification of a collagen production-promoting factorfrom an extract of royal jelly and its possible mechanism.
Koya-Miyata S, Okamoto I, Ushio S, Iwaki K, Ikeda M, KurimotoM.
Biosci Biotechnol Biochem. 2004 Apr;68(4):767-73.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/15118301
Effectiveness of royal jelly on tympanic membraneperforations: an experimental study.
Calli C, Tugyan K, Oncel S, Pinar E, Demirtaşoglu F, CalliAO, Tolon B, Yilmaz O, Kiray A.
J Otolaryngol Head Neck Surg. 2008 Apr;37(2):179-84.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/19128609

10. A potent antibacterial protein in royal jelly.Purification and determination of the primary structure ofroyalisin.
Fujiwara S, Imai J, Fujiwara M, Yaeshima T, Kawashima T,Kobayashi K.
J Biol Chem. 1990 Jul 5;265(19):11333-7.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/2358464
Protective potential of Royal Jelly against carbontetrachloride induced-toxicity and changes in the serum sialic acidlevels.
Cemek M, Aymelek F, Büyükokuroğlu ME, Karaca T, Büyükben A,Yilmaz F.
Food Chem Toxicol. 2010 Oct;48(10):2827-32.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/20637822
[Influence of honey, royal jelly and propolis onaccelerating acetate healing of experimental gastric ulcers inrats].
Belostotskiĭ NI, Kas'ianenko VI, Dubtsova EA, Lazebnik LB.
Eksp Klin Gastroenterol. 2009;(6):46-50.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/20201286
The effects of royal jelly on liver damage induced byparacetamol in mice.
Kanbur M, Eraslan G, Beyaz L, Silici S, Liman BC, AltinorduluS, Atasever A.
Exp Toxicol Pathol. 2009 Mar;61(2):123-32. Epub 2008 Aug 6.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/18693095
Evaluation of the immunomodulatory activities of royaljelly components in vitro.
Gasic S, Vucevic D, Vasilijic S, Antunovic M, Chinou I, ColicM.
Immunopharmacol Immunotoxicol. 2007;29(3-4):521-36
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/18075862
Antioxidant properties of enzymatic hydrolysates fromroyal jelly.
Nagai T, Inoue R, Suzuki N, Nagashima T.
J Med Food. 2006 Fall;9(3):363-7.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/17004899
The immunostimulatory effect of the recombinant apalbumin1-major honeybee royal jelly protein-on TNFalpha release.
Majtán J, Kovácová E, Bíliková K, Simúth J.
Int Immunopharmacol. 2006 Feb;6(2):269-78.
Slovak Academy fo Sciences:http://www.zoo.sav.sk/data/people_publictions_976_Majtan_et_al_completed.pdf
Trace and mineral elements in royal jelly and homeostaticeffects.
Stocker A, Schramel P, Kettrup A, Bengsch E.
J Trace Elem Med Biol. 2005;19(2-3):183-9.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/16325534
Oral administration of royal jelly facilitates mRNAexpression of glial cell line-derived neurotrophic factor andneurofilament H in the hippocampus of the adult mouse brain.
Hashimoto M, Kanda M, Ikeno K, Hayashi Y, Nakamura T, OgawaY, Fukumitsu H, Nomoto H, Furukawa S.
Biosci Biotechnol Biochem. 2005 Apr;69(4):800-5.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/15849420
Jelleines: a family of antimicrobial peptides from theRoyal Jelly of honeybees (Apis mellifera).
Fontana R, Mendes MA, de Souza BM, Konno K, César LM,Malaspina O, Palma MS.
Peptides. 2004 Jun;25(6):919-28.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/15203237

20. Royal jelly inhibits the production of proinflammatorycytokines by activated macrophages.
Kohno K, Okamoto I, Sano O, Arai N, Iwaki K, Ikeda M,Kurimoto M.
Biosci Biotechnol Biochem. 2004 Jan;68(1):138-45.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/14745176
Signal transduction mechanism leading to enhancedproliferation of primary cultured adult rat hepatocytes treatedwith royal jelly 57-kDa protein.
Kamakura M.
J Biochem. 2002 Dec;132(6):911-9.
Oxford Journals:http://jb.oxfordjournals.org/content/132/6/911.abstract
Suppression of allergic reactions by royal jelly inassociation with the restoration of macrophage function and theimprovement of Th1/Th2 cell responses.
Oka H, Emori Y, Kobayashi N, Hayashi Y, Nomoto K.
Int Immunopharmacol. 2001 Mar;1(3):521-32.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/11367535
Fifty-seven-kDa protein in royal jelly enhancesproliferation of primary cultured rat hepatocytes and increasesalbumin production in the absence of serum.
Kamakura M, Suenobu N, Fukushima M.
Biochem Biophys Res Commun. 2001 Apr 13;282(4):865-74.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/11352630
A royal jelly as a new potential immunomodulator in ratsand mice.
Sver L, Orsolić N, Tadić Z, Njari B, Valpotić I, Basić I.
Comp Immunol Microbiol Infect Dis. 1996 Jan;19(1):31-8.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/8654043
Augmentation of wound healing by royal jelly (RJ) instreptozotocin-diabetic rats.
Fujii A, Kobayashi S, Kuboyama N, Furukawa Y, Kaneko Y,Ishihama S, Yamamoto H, Tamura T.
Jpn J Pharmacol. 1990 Jul;53(3):331-7.
Pubmed: http://www.ncbi.nlm.nih.gov/pubmed/2391765